BYETTA PI PDF

Learn about BYETTA, the BYETTA Pen. Important Safety Information for BYETTA (exenatide) injection. Contraindications. BYETTA is contraindicated in. Exenatide (Byetta) is the first in a new class of incretin peptide mimetics .. Available at ; accessed October 15, 3. Meneilly. Exenatide (marketed as Byetta, Bydureon) is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) medication, belonging to the group of incretin.

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Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a byetga cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. If response is inadequate, the dose may be increased to 10 mcg twice daily after 1 month of therapy. Views Read Edit View history. If pancreatitis li suspected, BYETTA should be discontinued promptly and should not be restarted if pancreatitis is confirmed.

Clinical trials have shown a benefit to adding exenatide to metformin and sulfonylureas. Byetta may affect the way some medicines work and some other medicines may affect the way Byetta works. Medicines byefta sometimes prescribed for purposes other than those listed in a Medication Guide. If you are having problems using your Byetta Pen, call po free No differences in safety or effectiveness were observed between these patients and younger patients.

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In healthy individuals, robust insulin secretion occurs during the first 10 minutes following intravenous IV glucose administration. Section 3 Now that you have done the one-time-only new pen setup, follow Section 3 for all of your injections. Failure to follow these instructions completely may result in a wrong dose, a broken pen or an infection. Withdrawal rates were not statistically significant across the treatment arms but were higher in the placebo group because of lack of glucose control.

No placebo-treated patients withdrew nyetta to nausea or vomiting.

Lower glucagon concentrations lead to bystta hepatic byettw output and decreased insulin demand. In patients with type 2 diabetes, Byetta moderates glucagon secretion and lowers serum glucagon concentrations during periods of hyperglycemia. What if I cannot pull, turn, or push the dose knob? In patients with end-stage renal disease receiving dialysis, single doses of Byetta 5 mcg were not well tolerated due to gastrointestinal side effects.

If you see more than one drop:.

Exenatide (Byetta) as a novel treatment option for type 2 diabetes mellitus

C Risk not ruled out. Each prefilled pen will deliver 60 doses to provide for 30 days of twice daily administration BID. One of the three patients experienced severe hypoglycemia requiring parenteral glucose administration.

Talk to your healthcare provider first if you are breastfeeding or plan to breastfeed. However, exenatide is present at low concentrations less than or equal to 2. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Antibodies to exenatide were not assessed in the week placebo-controlled trial of Byetta used in byettta with insulin glargine. There were no changes in hour mean systolic and diastolic blood pressure.

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With a Thiazolidinedione 16 Weeks. Despite best efforts, monotherapy or combination therapy of metformin and a sulfonylurea fails in many patients.

The pain may be felt going from your abdomen through to your back. The mean baseline HbA 1c values were 7. Byetta should be used with caution in patients receiving oral medications that have narrow therapeutic index or require rapid gastrointestinal absorption [see Adverse Reactions 6. Byetta did not significantly alter the pharmacodynamic properties e. Patients should be advised to inform their physicians if they are pregnant or intend to become pregnant.

Table 7 summarizes the study results for the and week clinical trials. Thyrotropin alfa TSH thyrotropin. If there is worsening glycemic control or byetga to achieve targeted glycemic control, alternative antidiabetic therapy should be considered [see Adverse Reactions 6.

Byetta – FDA prescribing information, side effects and uses

Exenatide was negative in the in vivo mouse micronucleus assay. Go to Healthcare Professional Site.

Based on postmarketing data BYETTA has been associated with acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis.