Observou-se um caso de resistência à eritropoetina recombinante humana causada por Ectasia Vascular Antral Gástrica em uma mulher de 40 anos de idade. Abstract. DAL MASO, Rosina Conceição Graçaplena et al. Sex hormones in women on dialysis. Rev. Assoc. Med. Bras. [online]. , vol, n.4, pp . 22 out. Observou-se um caso de resistência à eritropoetina recombinante humana causada por Ectasia Vascular Antral. Gástrica em uma mulher de.

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Regulação da produção da eritropoietina e perspectivas terapêuticas na anemia

Gastric antral vascular ectasia: Recombinant human erythropoietin alpha modulates the effects of radiotherapy on colorectal cancer microvessels. There are two main forms of GAVE.

There are two GATA inhibitors reported: We observed gastrointestinal blood loss by rectal examination that was positive for melena and the presence of occult blood in recombinantr stool in this patient.

Peginesatide as a new approach for treating anemia of CKD patient: Rocha, Vera Lucia Leite Published: Am J Physiol Renal Physiol ; 1: Rheumatology Oxford ;51 recombinantd Due to cell death reduction, both compensatory hypertrophic response and inflammation are attenuated, preventing a misfit remodelling Regular transfusions increased the risk of infection, iron overload and anti-HLA human leukocyte antigen antibodies development, reducing the likelihood of a successful renal transplantation.

Steroid therapy, of limited efficacy, presented important side effects, such as hirsutism, virilization and hepatotoxicity, and was withdrawn Erythropoietin acts co-ordinately at various levels, which includes: Some associated factors such as autoimmune disease, hemolysis, heart and liver disease were discarded on physical examination and complementary tests.


Erythropoietin protects against diabetes through direct effects on pancreatic beta cells.

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Erythropoietin blocks tumour cells apoptosis and potentiates angiogenesis, with increased tumour growth, metastases and reduction of eritroooetina radiotherapy response It is a potential alternative to IV iron requirement, which reduces risk and side effects associated to this treatment, restoring effectiveness of oral iron therapy and increasing iron release from the reticuloendothelial system Escorcio, Carla Solange de Melo Published: These pro-inflammatory cytokines contribute to anaemia and EPO resistance.

Bregman R, Pecoits-Filho R. Manipulation of the hepcidin pathway for therapeutic purposes.

Erythropoietin EPOformerly named haemopoietin is essential to erythropoiesis. She had not provided any history of hematuria, gastrointestinal, cardiac, liver or collagen disease. Since then, several ESAs have appeared, characterized by lower administration frequency and better stabilization of haemoglobin concentration.

Oral administration of K inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease. The diagnosis of GAVE is based on the clinical history and endoscopic appearance.

Similarly to the kidney, the liver responds to hypoxia increasing the number of EPO hepatocyte producers, located around the central vein.


Hepcidin neutralization by an antihepcidin monoclonal antibody, tested in a mouse model of inflammatory anaemia caused by Brucella abortus heatkilledovercame EPO resistance. Crit Rev Oncol Hematol ;67 1: One of the major concerns is related to possible vascular endothelial growth factor VEGF activation, which may enhance tumour growth and proliferative diabetic retinopathy. Cell Signal ;23 The EPO production is controlled by transcriptional and post-transcriptional oxygendependent mechanisms.

In fact, EPO synthesized by these cells tends to act more locally, modulating, for example, regional angiogenesis and cell viability In this work, based on a literature search of studies using MEDLINE, our objective is to review the regulation of erythropoietin production and its functions, as well as treatment approach for anaemia of chronic kidney disease, with particular focus on new therapies.

Knowing that EPO has other functions, and also that regulators of the EPO gene are at the same time regulators of many other genes, we present a review on this issue. J Clin Invest ; Erythropoietin protects against ischaemic acute renal injury.

Clinical Queries Nephrology ;1 3: Erythropoietin has an action that exceeds erythropoiesis and plays an important role in cell protection.