Heinz Nixdorf Recall Study. Cardiovascular diseases are still the most frequent cause of death in the industrialized countries. Unfortunately, myocardial. Initiated in , the Heinz Nixdorf Recall Study involved 4, European participants. The results proved, for the first time, the connection. Request PDF on ResearchGate | Die Heinz Nixdorf Recall Studie | The Heinz Nixdorf Recall Study is a population-based study that aims to improve the.
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The study was initiated in the late s and enrolled a total of 4, participants aged years between December and August The Heinz Nixdorf Recall Study is a population-based study that aims to improve the prediction of cardiovascular events by integrating new imaging and non-imaging modalities in stude assessment.
Multiple studies have underlined the ability of CAC score for individual risk stratification and, accordingly, the American Heart Association recommended cardiac CT for risk assessment in individuals with an intermediate risk of cardiovascular events as measured by Framingham Risk Score. Currently, the year follow-up is under way and is estimated to be finished in July One focus of the study is the evaluation of the quantification of subclinical coronary artery calcifications coronary artery calcification, CAC as a prognostic factor in predicting cardiac events.
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Moreover, data on implications for reclassification into higher- or lower-risk groups based on CAC scores were lacking. The Heinz Nixdorf Recall Niddorf will significantly extend our knowledge about new modalities in the prediction of cardiac events.
A 5-year follow-up examination took place between and However, limitations in transcribing risk stratification algorithms based on American cohort studies into European populations have been acknowledged in the past. This article discusses the present findings of the Heinz Nixdorf Recall Study with respect to the current literature, risk stratification algorithms, and current European guidelines for risk prediction.
The Heinz Nixdorf Recall HNR study is a population-based cohort study that investigated the ability of CAC scoring in risk prediction for major cardiovascular events above and beyond traditional cardiovascular risk factors. Primary endpoints are myocardial infarction and sudden cardiac death.
Extending the original aims of the study, serial CAC measurements will allow the characterization of the natural history of CAC dynamics, the identification of its determinants and an understanding of the impact of CAC progression on the primary endpoints. Non-contrast-enhanced computed tomography CT imaging of the heart enables noninvasive quantification of coronary artery calcification CACa surrogate marker of the atherosclerotic burden in the coronary artery tree.
According to Heinz Nixdorf Recall reecall, CAC can be used for reclassification, especially in those in the intermediate-risk group, to advise on lifestyle changes for the reclassified low-risk category, or to implement intensive treatments for the reclassified high-risk individuals.